最新消息

從細胞到個體、從個人到群體、從人群到動物、從體內保健到生態環保,GMI免疫調節蛋白全面地提供了良性循環的基礎。

GMI免疫調節蛋白有高度的協同性、安全性及有效性,已具備新藥開發的資格。

GMI Certification
GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells 2021-11-15

Abstract

β-catenin is important in development of lung cancer. In our previous study, GMI, a fungal immunomodulatory protein, inhibits lung cancer cell survival. The aim of this study is to evaluate the effect of GMI on β-catenin inhibition and apoptosis induction. GMI induced apoptosis in lung cancer cells bearing wild-type and mutated EGFR. GMI did not reduce the β-catenin mRNA expression but suppressed the protein expressions of β-catenin that resulted in the transcriptional downregulation of its target genes: survivin and cyclin-D1. The transcriptional activation activity of β-catenin was demonstrated by TOPFLASH/FOPFLASH luciferase reporter assay. Inhibition of GSK-3β and proteasome blocked the inhibiting effect of GMI on β-catenin and its target genes. β-catenin silencing increased activation of apoptosis in GMI-treated H1355 cells. This is the first study to reveal the novel function of GMI in inducing apoptosis via β-catenin inhibition. These results provide a new potential of GMI in against lung cancer.

 

資料來源:https://doi.org/10.1002/tox.22582

參展資料:台灣:發現GMI抗肺癌的最新作用機制: GMI 能抑制β-catenin生成,促進egfr陽性非小細胞肺癌凋亡

聯絡我們
聯絡位置

222 新北市深坑區北深路三段270巷12號8樓之1

聯絡電話

+886-2-2662-0148