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從細胞到個體、從個人到群體、從人群到動物、從體內保健到生態環保，GMI免疫調節蛋白全面地提供了良性循環的基礎。

GMI免疫調節蛋白有高度的協同性、安全性及有效性，已具備新藥開發的資格。

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Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum 2021-11-15

Abstract

Background and purpose: Autophagic cell death is considered a self-destructive process that results from large amounts of autophagic flux. In our previous study, GMI, a recombinant fungal immunomodulatory protein cloned from Ganoderma microsporum, induced autophagic cell death in lung cancer cells. The aim of this study was to examine the role of autophagosome accumulation in GMI-mediated cell death.

 

資料來源:https://doi.org/10.1111/j.1476-5381.2012.02073.x

 

延伸閱讀
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion
GMI, Ganoderma microsporum protein, suppresses cell mobility and increases temozolomide sensitivity through induction of Slug degradation in glioblastoma multiforme cells
Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats
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熱門文章
1. Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells
2. GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells
3. GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition
4. A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells
5. Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells
熱門影音
靈芝蛋白GMI能幫助打造抗癌體質! 台大教授許瑞祥博士﹔雙向調節機制改善免疫失調
靈芝蛋白GMI能幫助打造抗癌體質! 台大教授許瑞祥博士﹔雙向...
靈芝蛋白GMI能幫助打造抗癌體質! 台大教授許瑞祥博士﹔雙向...
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